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Interaction of serotonergic antidepressants and opioid analgesics: is serotonin syndrome going undetected? Moreover, animal research and at the least three human case reports have discovered no interplay between ketamine and the monoamine oxidase inhibitor (MAOI) tranylcypromine, which is of importance as the mixture of a monoamine reuptake inhibitor with an MAOI can produce severe toxicity such as serotonin syndrome or hypertensive crisis. A small variety of adults and kids 5 years of age and older (about 1 in 500 individuals) who took anticonvulsants comparable to diazepam to treat varied conditions during clinical studies turned suicidal during their therapy.

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